Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
Posted on 2018-05-22 - 05:00
Abstract Background Tonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis. Methods Tonsils of 89 surgical patients with tonsillar hypertrophy (n = 47) or recurrent tonsillitis (n = 42) were analysed. Patients were carefully characterized clinically. Standard questionnaire was used to asses preceding and allergy symptoms. Respiratory viruses were analysed in tonsils and nasopharynx by PCR. Quantitative real-time PCR was used to analyse intratonsillar gene expressions of IFN-α, IFN-β, IFN-γ, IL-10, IL-13, IL-17, IL-28, IL-29, IL-37, TGF-β, FOXP3, GATA3, RORC2 and Tbet. Results Median age of the subjects was 15 years (range 2–60). Patients with tonsillar hypertrophy were younger, smoked less often, had less pollen allergy and had more adenovirus, bocavirus-1, coronavirus and rhinovirus in nasopharynx (all P < 0.05). Only bocavirus-1 was more often detected in hypertrophic tonsils (P < 0.05). In age-adjusted analysis, tonsillar hypertrophy was associated with higher mRNA expressions of IL-37 (P < 0.05). Conclusions Intratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independently associated with tonsillar hypertrophy showing slightly stronger anti-inflammatory response in these patients.
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Mikola, Emilia; Elenius, Varpu; Saarinen, Maria; Palomares, Oscar; Waris, Matti; Turunen, Riitta; et al. (2018). Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4107674.v1
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AUTHORS (17)
EM
Emilia Mikola
VE
Varpu Elenius
MS
Maria Saarinen
OP
Oscar Palomares
MW
Matti Waris
RT
Riitta Turunen
TP
Tuomo Puhakka
LI
Lotta Ivaska
BR
Beate Rückert
AA
Alar Aab
TV
Tero Vahlberg
TV
Tytti Vuorinen
TA
Tobias Allander
CC
Carlos Camargo
MA
Mübeccel Akdis
CA
Cezmi Akdis
TJ
Tuomas Jartti