The solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney
Posted on 15.02.2021 - 08:56 by Sofia Verouti
In the absence of Slc16a12, urinary losses of GAA are not adequately compensated by increased tubular synthesis, caused by feedback inhibition of the rate limiting enzyme L-arginine:glycine amidinotransferase by creatine in proximal tubular cells.
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Verouti, Sofia; Lambert, Delphine; Mathis, Déborah; Pathare, Ganesh; Escher, Geneviève; Vogt, Bruno; et al. (2021): The solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.5233718.v2
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