The LUMIERE Dataset: Longitudinal Glioblastoma MRI with Expert RANO Evaluation

This is a single-center longitudinal Glioblastoma MRI dataset with expert ratings of selected follow-up studies according to the response assessment in neuro-oncology criteria (RANO). The expert rating includes details about the rationale of the ratings. For a subset of patients, we provide pathology information regarding methylation of the O6-methylguanine-DNA methyltransferase (MGMT) and isocitrate dehydrogenase 1 (IDH1), as well as the overall survival time. The MRI data includes T1-weighted pre- and post-contrast, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) MRI. Segmentations from state-of-the-art automated segmentation tools (DeepBraTumIA, HD-GLIO-AUTO), as well as radiomic features, complement the imaging data. This collection includes MRI data of 91 GBM patients with a total of 638 study dates and 2487 images. Possible applications of this dataset are radiomics research, the development and validation of automated segmentation methods, and studies on response assessment.