The First Synthesis of Enantiopure α-Amino Ketimines and Amino
Aziridines

Forcén-Acebal, Ángela

The First Synthesis of Enantiopure α-Amino Ketimines and Amino Aziridines

Posted on 2001-03-20 - 00:00

Chiral 1-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from 1-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneus cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization.

CITE THIS COLLECTION

Concellón, José M.; Bernad, Pablo L.; Riego, Estela; García-Granda, Santiago; Forcén-Acebal, Ángela (2016). The First Synthesis of Enantiopure α-Amino Ketimines and Amino Aziridines. ACS Publications. Collection. https://doi.org/10.1021/jo005741x

https://doi.org/10.1021/jo005741x

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