Synthesis and N‑Methyl‑d‑aspartate (NMDA) Receptor Activity of Ketamine Metabolites
Posted on 2017-08-22 - 20:15
Ketamine
is rapidly metabolized in the human body to a variety
of metabolites, including the hydroxynorketamines. At least
two hydroxynorketamines have significant antidepressant action
in rodent models, with limited action against the N-methyl-d-aspartate (NMDA) receptor. The synthesis of 12
hydroxynorketamines and their binding affinity to the NMDA receptor
is presented here.
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Morris, Patrick J.; Moaddel, Ruin; Zanos, Panos; Moore, Curtis E.; Gould, Todd; Zarate, Carlos A.; et al. (2017). Synthesis and N‑Methyl‑d‑aspartate (NMDA) Receptor Activity of Ketamine Metabolites. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02177
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AUTHORS (7)
PM
Patrick J. Morris
RM
Ruin Moaddel
PZ
Panos Zanos
CM
Curtis E. Moore
TG
Todd Gould
CZ
Carlos A. Zarate
CT
Craig J. Thomas