Supplementary material from "Vincenzo Cerundolo. 20 December 1959 - 07 January 2020"

Enzo made a great impact in Immunology, particularly in the unravelling of the antigen processing system for peptides presented by class I proteins of the Major Histocompatibility Complex (MHC), working with Alain Townsend. He then moved on to explore the related CD1 proteins that present lipids as antigens to T lymphocytes and Natural Killer (NK) cells. In collaboration with Yvonne Jones FRS they solved how these lipids bind to CD1 molecules and how antigen specificity is achieved. He also made many contributions to cancer immunology and was actively involved in the design and conduct of clinical cancer immunotherapy trials.