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Supplementary material from "Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces"

Version 2 2017-01-10, 12:17
Version 1 2016-12-19, 11:10
Posted on 2017-01-10 - 12:17
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material–tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.

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Journal of the Royal Society Interface

AUTHORS (16)

Leigh Townsend
Richard Williams
Olachi Anuforom
Matthew R. Berwick
Fenella Halstead
E. Hughes
Artemis Stamboulis
Beryl Oppenheim
Julie Gough
Liam Grover
Rob Scott
Mark Webber
Anna F. A. Peacock
Antonio Belli
Ann Logan
Felicity de Cogan
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