Supplementary material from "Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces"
Version 2 2017-01-10, 12:17
Version 1 2016-12-19, 11:10
Posted on 2017-01-10 - 12:17
The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material–tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.
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Townsend, Leigh; Williams, Richard; Anuforom, Olachi; Berwick, Matthew R.; Halstead, Fenella; Hughes, E.; et al. (2016). Supplementary material from "Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.3647720.v2
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AUTHORS (16)
LT
Leigh Townsend
RW
Richard Williams
OA
Olachi Anuforom
MB
Matthew R. Berwick
FH
Fenella Halstead
EH
E. Hughes
AS
Artemis Stamboulis
BO
Beryl Oppenheim
JG
Julie Gough
LG
Liam Grover
RS
Rob Scott
MW
Mark Webber
AF
Anna F. A. Peacock
AB
Antonio Belli
AL
Ann Logan
Fd
Felicity de Cogan