Superstructural Raman Nanosensors with Integrated
Dual Functions for Ultrasensitive Detection and Tunable Release of
Molecules
Version 2 2018-07-20, 17:49
Version 1 2018-07-16, 13:06
Posted on 2018-07-20 - 17:49
It
is highly desirable but extremely difficult to actively control
the release dynamics of molecules from nanoparticle carriers and monitor
the release process in real time. In this work, we report the design,
fabrication, and manipulation of a superstructural Raman nanosensor,
offering integrated dual functions in ultrasensitive biodetection
and dynamic control in molecule release. The device has a designed
porous superstructure consisting of gold (Au) nanorod cores and silica
shells embedded with arrays of nanocavities arranged in concentric
layers in three-dimensions (3D), where high-density plasmonic silver
(Ag) nanoparticles are grown both in the nanocavities and on the outer
surfaces. The Ag nanoparticles provide substantially enhanced Raman
sensitivity for detection of molecules owing to the large number of
hotspots as well as the near-field coupling of Ag nanoparticles due
to their 3D concentric arrangement. Furthermore, by controlling the
external electric field, the release of molecules can be facilely
controlled at tunable rates owing to the induced electrokinetics at
the junctions of Ag nanoparticles. Finally, the biosensing-release-unibody
devices can be readily motorized, including transport and rotation,
which opens new opportunities for single-cell bioresearch and precision
medicine.
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3D Printing in Medicine
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Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
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Liu, Jing; Guo, Jianhe; Meng, Guowen; Fan, Donglei (2018). Superstructural Raman Nanosensors with Integrated
Dual Functions for Ultrasensitive Detection and Tunable Release of
Molecules. ACS Publications. Collection. https://doi.org/10.1021/acs.chemmater.8b01979
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AUTHORS (4)
JL
Jing Liu
JG
Jianhe Guo
GM
Guowen Meng
DF
Donglei Fan