Superior Fluorogen-Activating Protein Probes Based
on 3‑Indole–Malachite Green
Posted on 2017-08-17 - 21:10
A series
of novel fluorogenic dyes based on 3-indole–Malachite
Green, MGs 5–7, have been developed
that are dark in solution but highly fluorescent when bound to the
cognate reporter, fluorogen-activating protein (FAP). Significantly,
the new MGs 5–7 probes are superior
to the traditional MG 1 with high fluorescent efficiency
and low toxicity to cells while maintaining the large “pseudo-Stokes”
shifts (Δλ = λex – λem) and the malachite green (MG)-like fluorescence OFF–ON
switching mechanism in both live mammalian cells and bacterial cells
when bound to FAP.
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Zhang, Qingyang; Wang, Qinghua; Sun, Ying; Zuo, Limin; Fetz, Verena; Hu, Hai-Yu (2017). Superior Fluorogen-Activating Protein Probes Based
on 3‑Indole–Malachite Green. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02055
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AUTHORS (6)
QZ
Qingyang Zhang
QW
Qinghua Wang
YS
Ying Sun
LZ
Limin Zuo
VF
Verena Fetz
HH
Hai-Yu Hu