Structurally Diverse Diterpenoids from Isodon
scoparius and Their Bioactivity
Posted on 2017-06-27 - 15:23
Fourteen new diterpenoids (1–14) based on four skeletal types and
two known analogues (15 and 16) were isolated
from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring
a 1,11-ether bridge, and
the structures of these new compounds were established mainly by NMR
and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined
using single-crystal X-ray diffraction. The absolute configuration
of 14 was determined by comparison of the experimental
and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against
five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480),
and they also inhibited NO production in LPS-stimulated RAW264.7 cells,
with IC50 values of 1.0, 3.1, and 1.8 μM, respectively.
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Jiang, Hua-Yi; Wang, Wei-Guang; Tang, Jian-Wei; Liu, Miao; Li, Xing-Ren; Hu, Kun; et al. (2017). Structurally Diverse Diterpenoids from Isodon
scoparius and Their Bioactivity. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.7b00163
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AUTHORS (11)
HJ
Hua-Yi Jiang
WW
Wei-Guang Wang
JT
Jian-Wei Tang
ML
Miao Liu
XL
Xing-Ren Li
KH
Kun Hu
XD
Xue Du
XL
Xiao-Nian Li
HZ
Hong-Bin Zhang
JP
Jian-Xin Pu
HS
Han-Dong Sun