Stereoselective Three-Component Synthesis of
trans-endo-Decahydroquinolin-4-one Derivatives from Aldehydes,
Aniline, and Acetylcyclohexene

Yao, Ching-Fa

Stereoselective Three-Component Synthesis of trans-endo-Decahydroquinolin-4-one Derivatives from Aldehydes, Aniline, and Acetylcyclohexene

Posted on 2006-08-18 - 00:00

The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one (4) via a three-component reaction of aldehydes (1), anilines (2), and 1-acetylcyclohexene (3) in the presence of iodine in a one-pot reaction at room temperature is described. The short reaction time, easy workup, excellent yield, and mild reaction conditions make this novel annulation strategy both practical and attractive.

CITE THIS COLLECTION

Lin, Chunchi; Fang, Hulin; Tu, Zhijay; Liu, Ju-Tsung; Yao, Ching-Fa (2016). Stereoselective Three-Component Synthesis of trans-endo-Decahydroquinolin-4-one Derivatives from Aldehydes, Aniline, and Acetylcyclohexene. ACS Publications. Collection. https://doi.org/10.1021/jo060992c

https://doi.org/10.1021/jo060992c

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