Solubility and Speciation of Ketoprofen and Aspirin
in Supercritical CO2 by Infrared Spectroscopy
Posted on 2016-02-05 - 14:59
The
solubility of ketoprofen and aspirin in subcritical and supercritical
CO2 was measured using FTIR absorption spectroscopy in
the large range of temperature of 298.2–353.2 K and pressure
of 5–35 MPa. The evolution of the solubility of both active
pharmaceutical ingredients (APIs) was fitted using the Chrastil’s
equation. In addition, the speciation of both APIs in monomeric and
dimeric forms was explored by analyzing the characteristic carbonyl
stretching vibrations of the carboxylic acid functions assigned to
the dimers and monomers, respectively. Moreover, the evolution of
the dimerization constant K of the two drugs as a
function of the temperature and the pressure of scCO2 has
been reported.
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Champeau, Mathilde; Thomassin, Jean-Michel; Jérôme, Christine; Tassaing, Thierry (2016). Solubility and Speciation of Ketoprofen and Aspirin
in Supercritical CO2 by Infrared Spectroscopy. ACS Publications. Collection. https://doi.org/10.1021/acs.jced.5b00812
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AUTHORS (4)
- MCMathilde ChampeauJTJean-Michel ThomassinCJChristine JérômeTTThierry Tassaing
