Solid-Phase Synthesis of Carboxylic and
Oxamic Acids via OsO4/NaIO4/HMTA-Mediated Oxidative Cleavage of
Acetylenic Peptides

Meldal, Morten

Solid-Phase Synthesis of Carboxylic and Oxamic Acids via OsO₄/NaIO₄/HMTA-Mediated Oxidative Cleavage of Acetylenic Peptides

Posted on 2007-06-21 - 00:00

A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO₄/NaIO₄ mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.

CITE THIS COLLECTION

Nielsen, Thomas E.; T. Le Quement, Sebastian; Meldal, Morten (2016). Solid-Phase Synthesis of Carboxylic and Oxamic Acids via OsO₄/NaIO₄/HMTA-Mediated Oxidative Cleavage of Acetylenic Peptides. ACS Publications. Collection. https://doi.org/10.1021/ol070693p

https://doi.org/10.1021/ol070693p

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