Smartphone confocal microscopy for imaging cellular structures in human skin in vivo
Posted on 2018-03-26 - 15:42
We report development of a low-cost smartphone confocal microscope and its first demonstration of in vivo human skin imaging. The smartphone confocal microscope uses a slit aperture and diffraction grating to conduct two-dimensional confocal imaging without using any beam scanning devices. Lateral and axial resolutions of the smartphone confocal microscope were measured as 2 and 5 µm, respectively. In vivo confocal images of human skin revealed characteristic cellular structures, including spinous and basal keratinocytes and papillary dermis. Results suggest that the smartphone confocal microscope has a potential to examine cellular details in vivo and may help disease diagnosis in resource-poor settings, where conducting standard histopathologic analysis is challenging.
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Freeman, Esther; Semeere, Aggrey; Osman, Hany; Peterson, Gary; Rajadhyaksha, Milind; González, Salvador; et al. (2018). Smartphone confocal microscopy for imaging cellular structures in human skin in vivo. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.3976770.v1
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R. Rox Anderson