Smartphone confocal microscopy for imaging cellular structures in human skin in vivo
Posted on 2018-03-26 - 15:42
We report development of a low-cost smartphone confocal microscope and its first demonstration of in vivo human skin imaging. The smartphone confocal microscope uses a slit aperture and diffraction grating to conduct two-dimensional confocal imaging without using any beam scanning devices. Lateral and axial resolutions of the smartphone confocal microscope were measured as 2 and 5 µm, respectively. In vivo confocal images of human skin revealed characteristic cellular structures, including spinous and basal keratinocytes and papillary dermis. Results suggest that the smartphone confocal microscope has a potential to examine cellular details in vivo and may help disease diagnosis in resource-poor settings, where conducting standard histopathologic analysis is challenging.
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Freeman, Esther; Semeere, Aggrey; Osman, Hany; Peterson, Gary; Rajadhyaksha, Milind; González, Salvador; et al. (2018). Smartphone confocal microscopy for imaging cellular structures in human skin in vivo. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.3976770.v1
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AUTHORS (10)
EF
Esther Freeman
AS
Aggrey Semeere
HO
Hany Osman
GP
Gary Peterson
MR
Milind Rajadhyaksha
SG
Salvador González
JM
Jeffery Martin
RA
R. Rox Anderson
GT
Gary Tearney
DK
DongKyun Kang