Selective Phosphoramidation and Phosphonation of Benzoxazoles via Sequence Control

Published on 2017-04-21T12:34:50Z (GMT) by
A selective phosphoramidation and phosphonation of benzoxazole was developed with trialkyl phosphites in the presence of iodine under mild conditions. In the reaction, the transformation completes in 10 min at room temperature and the substrates are well tolerant, as 2-substituted azoles could afford the quaternary carbon-centered products. Significantly, phosphites could be selectively introduced into the C- and N-positions of the benzoxazoles by controlling the addition sequence and the ratio of substrates.

Cite this collection

Huang, Ling; Gong, Jiuhan; Zhu, Zheng; Wang, Yufeng; Guo, Shengmei; Cai, Hu (2017): Selective Phosphoramidation and Phosphonation of Benzoxazoles

via Sequence Control. ACS Publications.

https://doi.org/10.1021/acs.orglett.7b00726

Retrieved: 23:57, Aug 18, 2017 (GMT)