Rapid Access to a Broad Range of 6′-Substituted
Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors

Miller, Stephen C.

Rapid Access to a Broad Range of 6′-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors

Version 3 2017-10-17, 19:04

Version 2 2017-10-17, 16:34

Version 1 2017-10-16, 21:03

Posted on 2017-10-17 - 19:04

Light-emitting firefly luciferin analogues contain electron-donating groups in the 6′-position, but the scope of known 6′-substitution remains narrow. A two-step route to a broad range of 6′-substituted luciferin analogues was developed to fill this void and enable more extensive study of the 6′-functionality. This chemistry allowed direct access to “caged” amide and bright azetidine analogues, but also revealed thioether inhibitors and unexpectedly luminogenic aryl amine derivatives.

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Sharma, Deepak K.; Adams, Spencer T.; Liebmann, Kate L.; Miller, Stephen C. (2017). Rapid Access to a Broad Range of 6′-Substituted Firefly Luciferin Analogues Reveals Surprising Emitters and Inhibitors. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02806

https://doi.org/10.1021/acs.orglett.7b02806

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