Programmed Negative Allostery with Guest-Selected Rotamers Control Anion–Anion Complexes of Stackable Macrocycles

Published on 2018-06-13T10:13:30Z (GMT) by
A new rotamer-based strategy for negative allostery has been used to control host–host interactions and product yield upon anion complexation. Coassembly of anion dimers as guests inside two cyanostar macrocycles drives selection of one rotamer in which all ten steric groups get directed outward to destabilize triply stacked macrocycles. A large entropy penalty (Δ<i>S</i>) is quantified upon anion binding when the multiple dynamic rotamers collapse down to one.

Cite this collection

Sheetz, Edward

G.; Qiao, Bo; Pink, Maren; Flood, Amar H. (2018): Programmed

Negative Allostery with Guest-Selected

Rotamers Control Anion–Anion Complexes of Stackable Macrocycles. ACS Publications. Collection.