Postmetalated Zirconium Metal Organic Frameworks as
a Highly Potent Bactericide
Posted on 2017-03-24 - 13:06
Metal–organic frameworks (MOFs)
have emerged as an important class of hybrid organic–inorganic
materials. One of the reasons they have gained remarkable attention
is attributed to the possibility of altering them by postsynthetic
modification, thereby providing access to new and novel advanced materials.
MOFs have been applied in catalysis, gas storage, gas separation,
chemical sensing, and drug delivery. However, their bactericidal use
has rarely been explored. Herein, we developed a two-step process
for the synthesis of zirconium-based MOFs metalated with silver cations
as a potent antibacterial agent. The obtained products were thoroughly
characterized by powder X-ray diffraction, scanning electron microscopy,
UV–visible, IR, thermogravimetric, and Brunauer–Emmett–Teller
analyses. Their potency was evaluated against E. coli with a reported minimal inhibitory concentration and minimal bactericidal
concentration of as low as 6.5 μg/mL of silver content. Besides
the novelty of the system, the advantage of this strategy is that
the MOFs could be potentially regenerated and remetalated after each
antibacterial test, unlike previously reported frameworks, which involved
the destruction of the framework.
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Mortada, Boushra; Matar, Tamara Abou; Sakaya, Aya; Atallah, Hala; Kara Ali, Zeinab; Karam, Pierre; et al. (2017). Postmetalated Zirconium Metal Organic Frameworks as
a Highly Potent Bactericide. ACS Publications. Collection. https://doi.org/10.1021/acs.inorgchem.7b00429
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AUTHORS (7)
BM
Boushra Mortada
TM
Tamara Abou Matar
AS
Aya Sakaya
HA
Hala Atallah
ZK
Zeinab Kara Ali
PK
Pierre Karam
MH
Mohamad Hmadeh