Photocatalytic Oxyamination of Alkenes: Copper(II) Salts as Terminal Oxidants in Photoredox Catalysis

Published on 2018-11-08T20:05:12Z (GMT) by
A photocatalytic method for the oxyamination of alkenes using simple nucleophilic nitrogen atom sources in place of prefunctionalized electrophilic nitrogen atom donors is reported. Copper­(II) is an inexpensive, practical, and uniquely effective terminal oxidant for this process. In contrast to oxygen, peroxides, and similar oxidants commonly utilized in non-photochemical oxidative methods, the use of copper­(II) as a terminal oxidant in photoredox reactions avoids the formation of reactive heteroatom-centered radical intermediates that can be incompatible with electron-rich functional groups. As a demonstration of the generality of this concept, it has been shown that diamination and deoxygenation reactions can also be accomplished using similar photooxidative conditions.

Cite this collection

Reed, Nicholas

L.; Herman, Madeline I.; Miltchev, Vladimir P.; Yoon, Tehshik P. (2018): Photocatalytic Oxyamination of Alkenes: Copper(II)

Salts as Terminal Oxidants in Photoredox Catalysis. ACS Publications. Collection.