PhI(OAc)2‑Promoted Site-Selective
C–H Chlorination of (Hetero)arenes with p‑Toluenesulfonyl
Chloride
Posted on 2024-10-07 - 12:03
An
efficient and practical system for metal-free catalytic chlorination
of (hetero)arenes by using readily available and inexpensive TsCl
and PhI(OAc)2 is described. This newly developed protocol
has been achieved by the nonsymmetric iodane generated by a combination
of PhI(OAc)2 and TsCl. The broad substrate scope, good
functional group tolerance, excellent regioselectivity, and short
reaction times make this method attractive for the late-stage chlorination
of complex drug-like scaffolds.
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Tang, Junyang; Liu, Yaorong; Qiu, Baojie; Zhang, Zhuo; Zhang, Xingxian (2024). PhI(OAc)2‑Promoted Site-Selective
C–H Chlorination of (Hetero)arenes with p‑Toluenesulfonyl
Chloride. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.4c03017
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AUTHORS (5)
- JTJunyang TangYLYaorong LiuBQBaojie QiuZZZhuo ZhangXZXingxian Zhang
