Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections
Posted on 2020-09-16 - 14:08
Coxsackievirus A24
variant (CVA24v) and human adenovirus 37 (HAdV-37)
are leading causative agents of the severe and highly contagious ocular
infections acute hemorrhagic conjunctivitis and epidemic keratoconjunctivitis,
respectively. Currently, neither vaccines nor antiviral agents are
available for treating these diseases, which affect millions of individuals
worldwide. CVA24v and HAdV-37 utilize sialic acid as attachment receptors
facilitating entry into host cells. Previously, we and others have
shown that derivatives based on sialic acid are effective in preventing
HAdV-37 binding and infection of cells. Here, we designed and synthesized
novel pentavalent sialic acid conjugates and studied their inhibitory
effect against CVA24v and HAdV-37 binding and infection of human corneal
epithelial cells. The pentavalent conjugates are the first reported
inhibitors of CVA24v infection and proved efficient in blocking HAdV-37
binding. Taken together, the pentavalent conjugates presented here
form a basis for the development of general inhibitors of these highly
contagious ocular pathogens.
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Johansson, Emil; Caraballo, Rémi; Mistry, Nitesh; Zocher, Georg; Qian, Weixing; Andersson, C. David; et al. (2020). Pentavalent Sialic Acid Conjugates Block Coxsackievirus
A24 Variant and Human Adenovirus Type 37–Viruses That Cause
Highly Contagious Eye Infections. ACS Publications. Collection. https://doi.org/10.1021/acschembio.0c00446
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AUTHORS (13)
EJ
Emil Johansson
RC
Rémi Caraballo
NM
Nitesh Mistry
GZ
Georg Zocher
WQ
Weixing Qian
CA
C. David Andersson
DH
Daniel L. Hurdiss
NC
Naresh Chandra
RT
Rebecca Thompson
LF
Lars Frängsmyr
TS
Thilo Stehle
NA
Niklas Arnberg
ME
Mikael Elofsson