Pd-Catalyzed Three-Component Reaction of Anilines,
Ethyl Vinyl Ether, and Nitro-Paraffin: Assembly of β‑Nitroamines

Jiang, Huanfeng

Pd-Catalyzed Three-Component Reaction of Anilines, Ethyl Vinyl Ether, and Nitro-Paraffin: Assembly of β‑Nitroamines

Posted on 2018-01-25 - 15:34

A novel palladium-catalyzed amination and nitration of ethyl vinyl ether for the construction of β-nitroamine derivatives under mild conditions has been developed. This transformation provides a new strategy for the installation of amino and nitro from aromatic amines and nitro-paraffin into alkenes. Morpholine resulted in the aza-Henry reaction, while DABCO led to the unexpected rearrangement.

CITE THIS COLLECTION

Ouyang, Lu; Zhan, Lingzhi; Li, Jianxiao; Zhang, Qiaoyu; Qi, Chaorong; Wu, Wanqing; et al. (2018). Pd-Catalyzed Three-Component Reaction of Anilines, Ethyl Vinyl Ether, and Nitro-Paraffin: Assembly of β‑Nitroamines. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b03631

https://doi.org/10.1021/acs.orglett.7b03631

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