Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum
adareanum

Baker, Bill J.

Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum adareanum

Posted on 2006-05-03 - 00:00

Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC₅₀ = 0.018 μM) and appears to operate via inhibition (IC₅₀ = 2 nM) of V-ATPase.

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Diyabalanage, Thushara; Amsler, Charles D.; McClintock, James B.; Baker, Bill J. (2016). Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum adareanum. ACS Publications. Collection. https://doi.org/10.1021/ja0588508

https://doi.org/10.1021/ja0588508

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