Palladium-Catalyzed Remote meta-Selective
C–H Bond Silylation and Germanylation
Posted on 2017-06-27 - 15:20
Selective meta-C–H activation of arenes
to date has met with a limited number of functionalizations. Expanding
the horizon of meta-C–H functionalization,
herein we disclose an unprecedented meta-silylation
and -germanylation protocol by employing a simple nitrile-based directing
template. Longer linkers between the target site and the directing
template were successfully explored for meta-silylation
(sp2-ε and sp2-ζ). Additionally,
synthetic utility was demonstrated with several postsynthetic elaborations
and with a formal synthesis of TAC101, a promising drug for the treatment
of lung cancer.
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Modak, Atanu; Patra, Tuhin; Chowdhury, Rajdip; Raul, Suman; Maiti, Debabrata (2017). Palladium-Catalyzed Remote meta-Selective
C–H Bond Silylation and Germanylation. ACS Publications. Collection. https://doi.org/10.1021/acs.organomet.7b00309
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AUTHORS (5)
AM
Atanu Modak
TP
Tuhin Patra
RC
Rajdip Chowdhury
SR
Suman Raul
DM
Debabrata Maiti