Palladium-Catalyzed Dehydrogenative Difunctionalization
of Aminoalkenes with Aminals as Oxidants and Electrophiles
Posted on 2017-08-22 - 20:30
A novel
palladium-catalyzed aminomethylamination of aminoalkenes
with an aminal, functioning not only as an aminomethylation reagent
but also as an oxidant, was developed. This direct and operationally
simple protocol provides a fundamentally novel and unique approach
toward the synthesis of 2-(2-aminoethyl)indoles and 2-(2-aminoethyl)pyrrolidines,
which are important building blocks in synthetic organic chemistry.
The unity of this method was highlighted by the rapid synthesis of
Alosetron, a drug used for the treatment of irritable bowel syndrome.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Li, Lixin; Zhou, Xibing; Yu, Bangkui; Huang, Hanmin (2017). Palladium-Catalyzed Dehydrogenative Difunctionalization
of Aminoalkenes with Aminals as Oxidants and Electrophiles. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02203
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (4)
LL
Lixin Li
XZ
Xibing Zhou
BY
Bangkui Yu
HH
Hanmin Huang