Palladium-Catalyzed
Carbonylative Hiyama–Denmark
Reaction toward the Synthesis of Aryl Carbonyl-Containing Oxindoles

Lian, Zhong

Palladium-Catalyzed Carbonylative Hiyama–Denmark Reaction toward the Synthesis of Aryl Carbonyl-Containing Oxindoles

Posted on 2022-12-29 - 15:10

A palladium-catalyzed domino Heck cyclization/carbonylative Hiyama–Denmark cross-coupling reaction between alkene-tethered aryl iodides and silylcarboxylic acids is presented. This reaction proceeds well without toxic carbon monoxide (CO) gas and has good functional group tolerance, providing an alternative access to carbonyl-containing oxindoles. In this transformation, silylcarboxylic acids play a dual role as a CO source and a nucleophile.

CITE THIS COLLECTION

Li, Xiong; Zhang, Xuemei; Xiong, Baojian; Lian, Zhong (2022). Palladium-Catalyzed Carbonylative Hiyama–Denmark Reaction toward the Synthesis of Aryl Carbonyl-Containing Oxindoles. ACS Publications. Collection. https://doi.org/10.1021/acs.joc.2c02479

https://doi.org/10.1021/acs.joc.2c02479

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