PFPE-Based Polymeric 19F MRI Agents: A
New Class of Contrast Agents with Outstanding Sensitivity
Posted on 2017-07-24 - 20:18
19F magnetic resonance imaging (MRI) is a powerful noninvasive
imaging technique with demonstrated potential for the detection of
important diseases. The major challenge in the design of 19F MRI agents is signal attenuation caused by the reduced solubility
and segmental mobility of probes with high numbers of fluorine atoms.
Careful choice of the fluorinated moiety is required to maintain image
quality at the fluorine contents required for high imaging sensitivity.
Here we report the synthesis of perfluoropolyether (PFPE) end-functionalized
homopolymers of oligo(ethylene glycol) methyl ether acrylate (poly(OEGA)m-PFPE) as highly sensitive 19F
MRI contrast agents (CAs). The structural characteristics, conformation
and aggregation behavior, 19F NMR relaxation properties,
and 19F MR imaging were studied in detail. Dynamic light
scattering and molecular dynamics (MD) simulations were conducted
and demonstrated that poly(OEGA)m-PFPE
with the longest poly(OEGA)m segments
(m = 20) undergoes single-chain folding in water
while poly(OEGA)10-PFPE and poly(OEGA)4-PFPE
with shorter OEGA segments experience multiple-chain aggregation.
Long 19F T2 relaxation times
were measured for all poly(OEGA)m-PFPE
polymers in PBS and in the presence of serum (>80 ms), and no obvious
decrease in 19F T2 was observed
with increasing fluorine content up to ∼30 wt %. Moreover,
the signal-to-noise ratio increased linearly with increasing concentration
of fluorine, indicating that the PFPE-based polymers can be applied
as quantitative tracers. Furthermore, we investigated the in vivo behavior, in particular their biodistribution, of
the polymers with different aggregation properties. Control over the
balance of hydrophobicity and hydrophilicity allows manipulation of
the aggregation state, and this leads to different circulation behavior
in a murine model. This first report of the synthesis of polymeric
PFPE-based 19F MRI CAs demonstrates that these polymers
are an exciting new class of 19F MRI CAs with extremely
high fluorine content and outstanding imaging sensitivity.
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Zhang, Cheng; Moonshi, Shehzahdi Shebbrin; Han, Yanxiao; Puttick, Simon; Peng, Hui; Magoling, Bryan John Abel; et al. (2017). PFPE-Based Polymeric 19F MRI Agents: A
New Class of Contrast Agents with Outstanding Sensitivity. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.7b01285
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AUTHORS (11)
CZ
Cheng Zhang
SM
Shehzahdi Shebbrin Moonshi
YH
Yanxiao Han
SP
Simon Puttick
HP
Hui Peng
BM
Bryan John Abel Magoling
JR
James C. Reid
SB
Stefano Bernardi
DS
Debra J. Searles
PK
Petr Král
AW
Andrew K. Whittaker
KEYWORDS
Long 19 F T 2 relaxation timesfluorine contentmethyl ether acrylatePFPE-based 19 F MRI CAsimaging sensitivitynoninvasive imaging techniquePFPE-Based Polymeric 19 F MRI Agents19 F NMR relaxation properties19 F T 219 F MRI contrast agentsPBS19 F MR imagingMDpoly19 F MRI CAsOutstanding Sensitivity 19 F19 F MRI agentspolymerOEGA segments experience multiple-chain aggregation