Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes Initiated by Radical Alkylation with Tertiary α‑Carbonyl Alkyl Bromides

Published on 2018-02-12T21:09:08Z (GMT) by
A novel nickel-catalyzed remote arylation of alkenyl aldehydes triggered by radical alkylation with tertiary α-carbonyl alkyl bromides is described, thus producing a quaternary carbon center containing ketones in promising yields with broad functional group compatibility. Preliminary mechanistic studies suggest that the combination of a 1,<i>n</i>-HAT (<i>n</i> = 5 or 6) from alkyl radicals to aldehyde C–H bonds with nickel catalysis may account for the realization of this reaction.

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Jin, Weiwei; Zhou, Yulu; Zhao, Ying; Ma, Qianqian; Kong, Lichun; Zhu, Gangguo (2018): Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes

Initiated by Radical Alkylation with Tertiary α‑Carbonyl

Alkyl Bromides. ACS Publications.