Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes
Initiated by Radical Alkylation with Tertiary α‑Carbonyl
Alkyl Bromides
Posted on 2018-02-12 - 21:09
A novel nickel-catalyzed remote arylation
of alkenyl aldehydes triggered by radical alkylation with tertiary
α-carbonyl alkyl bromides is described, thus producing a quaternary
carbon center containing ketones in promising yields with broad functional
group compatibility. Preliminary mechanistic studies suggest that
the combination of a 1,n-HAT (n =
5 or 6) from alkyl radicals to aldehyde C–H bonds with nickel
catalysis may account for the realization of this reaction.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Jin, Weiwei; Zhou, Yulu; Zhao, Ying; Ma, Qianqian; Kong, Lichun; Zhu, Gangguo (2018). Nickel-Catalyzed Remote Arylation of Alkenyl Aldehydes
Initiated by Radical Alkylation with Tertiary α‑Carbonyl
Alkyl Bromides. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b00221
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (6)
WJ
Weiwei Jin
YZ
Yulu Zhou
YZ
Ying Zhao
QM
Qianqian Ma
LK
Lichun Kong
GZ
Gangguo Zhu
KEYWORDS
Bromidenickel catalysisarylationRadical Alkylationgroup compatibilityPreliminaryNickel-Catalyzed Remote Arylationquaternary carbon centercombinationnovel nickel-catalyzedrealizationalkenyl aldehydesα- carbonyl alkyl bromidesCarbonylAlkenyl Aldehydes Initiatedyieldalkyl radicalsketonealkylationTertiarybond