Nesteretal A, A Novel Class of Cage-Like Polyketide
from Marine-Derived Actinomycete Nesterenkonia halobia

Yang, Xian-Wen

Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia

Posted on 2019-08-17 - 18:13

An intriguing cage-like polyhemiketal, nesteretal A (1), was isolated from the coral-derived actinomycete Nesterenkonia halobia. Its structure was established by extensive spectroscopic and computational methods. Nesteretal A is a highly oxygenated compound featuring an unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic pathway of 1 from naturally occurring diacetyl was proposed. Compound 1 showed a weak retinoid X receptor-α (RXRα) transcriptional activation effect.

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Xie, Chun-Lan; Chen, Renzhi; Yang, Sihan; Xia, Jin-Mei; Zhang, Gai-Yun; Chen, Chao-Hong; et al. (2019). Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.9b02634

https://doi.org/10.1021/acs.orglett.9b02634

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