Neoclerodane Diterpenoids from Reehal Fatima, <i>Teucrium yemense</i>

Published on 2017-06-19T19:48:45Z (GMT) by
<i>Teucrium yemense</i> (Defl), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of <i>T. yemense</i> yielded six new neoclerodane diterpenoids, namely fatimanol A–E (<b>1</b>, <b>2</b>, <b>3</b>, <b>5</b>, and <b>6</b>) and fatimanone (<b>4</b>), and the known teulepicephin (<b>7</b>). As both the <i>Teucrium</i> genus and the related <i>Lamiaceae</i> family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterization of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles and by comparison to related compounds. The structure of fatimanol D (<b>5</b>) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.

Cite this collection

Nur-e-Alam, Mohammad; Yousaf, Muhammad; Ahmed, Sarfaraz; Al-Sheddi, Ebtesam S.; Parveen, Ifat; Fazakerley, David M.; Bari, Ahmed; Ghabbour, Hazem A.; Threadgill, Michael D.; Whatley, Kezia C. L.; Hoffmann, Karl F.; Al-Rehaily, Adnan J. (2017): Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense. ACS Publications.

https://doi.org/10.1021/acs.jnatprod.7b00188

Retrieved: 08:58, Nov 24, 2017 (GMT)