figshare
Browse

Multi-wavelength, en-face Photoacoustic Microscopy and Optical Coherence Tomography Imaging for Early and Selective Detection of Laser Induced Retinal Vein Occlusion

Posted on 2018-11-02 - 16:29
Multi-wavelength en face photoacoustic microscopy (PAM) was integrated with a spectral domain optical coherence tomography (SD-OCT) to evaluate optical properties of retinal vein occlusion (RVO) and retinal neovascularization (RNV) in living rabbits. The multi-wavelength PAM of the RVO and RNV were performed at several wavelengths ranging from 510 to 600 nm. Rose Bengal-induced RVO and RNV were performed and evaluated on eight rabbits using color fundus photography, fluorescein angiography, OCT, and spectroscopic en face PAM. In vivo experiment demonstrates that the spectral variation of photoacoustic response was achieved. The location and the treatment margins of the occluded vasculature as well as the morphology of individual RNV, were obtained with high contrast at a laser energy of 80 nJ, which was only half of the American National Standards Institute safety limit. In addition, dynamic changes in the retinal morphology and retinal neovascularization were administered using PA spectroscopy at numerous time points: 0, 3, 7, 14, 21, 28, and 35 days after photocoagulation. The proposed multi-wavelength spectroscopic PAM imaging may provide a potential imaging platform to differentiate occluded retinal vasculature and to improve characterization of microvasculature in a safe and efficient manner.

CITE THIS COLLECTION

DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
or
Select your citation style and then place your mouse over the citation text to select it.

SHARE

email
need help?