Multi-wavelength, en-face Photoacoustic
Microscopy and Optical Coherence Tomography
Imaging for Early and Selective Detection of
Laser Induced Retinal Vein Occlusion
Posted on 2018-11-02 - 16:29
Multi-wavelength en face photoacoustic microscopy (PAM) was integrated with a
spectral domain optical coherence tomography (SD-OCT) to evaluate optical properties of
retinal vein occlusion (RVO) and retinal neovascularization (RNV) in living rabbits. The
multi-wavelength PAM of the RVO and RNV were performed at several wavelengths ranging
from 510 to 600 nm. Rose Bengal-induced RVO and RNV were performed and evaluated on
eight rabbits using color fundus photography, fluorescein angiography, OCT, and
spectroscopic en face PAM. In vivo experiment demonstrates that the spectral variation of
photoacoustic response was achieved. The location and the treatment margins of the occluded
vasculature as well as the morphology of individual RNV, were obtained with high contrast at
a laser energy of 80 nJ, which was only half of the American National Standards Institute
safety limit. In addition, dynamic changes in the retinal morphology and retinal
neovascularization were administered using PA spectroscopy at numerous time points: 0, 3, 7,
14, 21, 28, and 35 days after photocoagulation. The proposed multi-wavelength spectroscopic
PAM imaging may provide a potential imaging platform to differentiate occluded retinal
vasculature and to improve characterization of microvasculature in a safe and efficient
manner.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Nguyen, Phuc; Li, Yanxiu; Zhang, Wei; Wang, Xueding; Paulus, Yannis (2018). Multi-wavelength, en-face Photoacoustic
Microscopy and Optical Coherence Tomography
Imaging for Early and Selective Detection of
Laser Induced Retinal Vein Occlusion. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4233749.v1
or
Select your citation style and then place your mouse over the citation text to select it.
Resource Link
SHARE
Usage metrics
AUTHORS (5)
PN
Phuc Nguyen
YL
Yanxiu Li
WZ
Wei Zhang
XW
Xueding Wang
YP
Yannis Paulus