Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2‑Hydroxypyridylmethylene Fragment

Chen, Dafa

Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2‑Hydroxypyridylmethylene Fragment

Posted on 2018-09-14 - 12:20

Reaction of complex [Cp*Ir(HOC₅H₃CH₂C₅H₃OH)Cl][Cl] (1) with AgOTf generated the product [Cp*Ir(HOC₅H₃CH₂C₅H₃OH)(H₂O)][OTf]₂ (2), which was further transformed to the complex [Cp*Ir(OC₅H₃CH₂C₅H₃O)(H₂O)] (3) in the presence of t-BuONa via −OH deprotonation. Complexes 1–3 exhibited high activity for the methylation of amines and ketones. These C–C and C–N coupling reactions proceeded in air with 1 mol % catalyst loading in the presence of K₂CO₃.

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Deng, Danfeng; Hu, Bowen; Yang, Min; Chen, Dafa (2018). Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2‑Hydroxypyridylmethylene Fragment. ACS Publications. Collection. https://doi.org/10.1021/acs.organomet.8b00575

https://doi.org/10.1021/acs.organomet.8b00575

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