Mechanical Stability of Lipid Membranes Decorated
with Dextran Sulfate
Posted on 2018-09-24 - 08:29
Lipid vesicles decorated with polysaccharides
have been proposed
as vehicles for drug delivery because the polymers confer to the vesicles
an enhanced stability, increasing the probability of the drug for
reaching the target cell. Here, we first test the affinity of dextran
sulfate (DS) for two different vesicle composition, and afterward,
we study the effect of DS on the liposome mechanical properties. We
found that DS binds to both tested membrane compositions. The interaction
of DS with the anionic membranes studied here is mediated by the metal
ions present in the aqueous solution (Na+ and Ca2+), being higher in the presence of Ca2+. Binding occurs
preferentially in regions of closely packed lipids. Strikingly, DS
did not affect the stability against detergent and the membrane rigidity
of none of the vesicles. Thus, the proposed stability increase induced
by this kind of polymers in drug delivery systems is not related with
a modulation of the membrane thermodynamic properties but to other
biochemical factors.
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Cámara, Candelaria
I.; Lurgo, Florencia E.; Fanani, Maria Laura; Wilke, Natalia (2018). Mechanical Stability of Lipid Membranes Decorated
with Dextran Sulfate. ACS Publications. Collection. https://doi.org/10.1021/acsomega.8b01537
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AUTHORS (4)
CC
Candelaria
I. Cámara
FL
Florencia E. Lurgo
MF
Maria Laura Fanani
NW
Natalia Wilke