Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge
Posted on 2017-04-28 - 11:49
Five new manzamine alkaloids (1–5) and new salt forms of two known manzamines
(6 and 7), along with seven known compounds
(8–14) of the same structural class,
were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis of the results of combined spectroscopic
analyses, the structure of kepulauamine A (1) was determined
to possess an unprecedented pyrrolizine moiety, while others were
functional group variants of known manzamines. These compounds exhibited
weak cytotoxicity, moderate antibacterial activity, and mild inhibition
against the enzyme isocitrate lyase.
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Kim, Chang-Kwon; Riswanto, Riswanto; Won, Tae Hyung; Kim, Heegyu; Elya, Berna; Sim, Chung J.; et al. (2017). Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.7b00121
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AUTHORS (9)
CK
Chang-Kwon Kim
RR
Riswanto Riswanto
TW
Tae Hyung Won
HK
Heegyu Kim
BE
Berna Elya
CS
Chung J. Sim
DO
Dong-Chan Oh
KO
Ki-Bong Oh
JS
Jongheon Shin