Manipulating the mitochondria activity in
human hepatic cell line Huh7 by low-power
laser irradiation
Posted on 2018-02-21 - 15:07
Low-power laser irradiation of red light has been recognized as a promising tool
across a vast variety of biomedical applications. However, deep understanding of the
molecular mechanisms behind laser-induced cellular effects remains a significant challenge.
Here, we investigated mechanisms involved in the death process in human hepatic cell line
Huh7 at a laser irradiation. We decoupled distinct cell death pathways targeted by laser
irradiations of different powers. Our data demonstrate that high dose laser irradiation
exhibited the highest levels of total reactive oxygen species production leading to cyclophilin
D-related necrosis via the mitochondrial permeability transition. On the contrary, low dose
laser irradiation resulted in nuclear accumulation of superoxide and apoptosis execution. Our
findings offer a novel insight into laser-induced cellular responses, and reveal distinct cell
death pathways triggered by laser irradiation. The observed link between mitochondria
depolarization and triggering ROS could be a fundamental phenomenon in laser-induced
cellular responses.
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Lynnyk, Anna; Lunova, Mariia; Jirsa, Milan; Egorova, Dasha; Kulikov, Andrey; Kubinová, Šárka; et al. (2018). Manipulating the mitochondria activity in
human hepatic cell line Huh7 by low-power
laser irradiation. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.3944092.v1
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AUTHORS (8)
AL
Anna Lynnyk
ML
Mariia Lunova
MJ
Milan Jirsa
DE
Dasha Egorova
AK
Andrey Kulikov
ŠK
Šárka Kubinová
OL
Oleg Lunov
AD
Alexandr Dejneka