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Manipulating Cellular Activities Using an Ultrasound–Chemical Hybrid Tool

Version 2 2017-10-12, 13:32
Version 1 2017-10-12, 13:27
Posted on 2017-10-12 - 13:32
We developed an ultrasound–chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.

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