Manipulating Cellular Activities Using an Ultrasound–Chemical Hybrid Tool

Published on 2017-10-12T13:32:44Z (GMT) by
We developed an ultrasound–chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.

Cite this collection

Fan, Ching-Hsiang; Huang, Yao-Shen; Huang, Wei-En; Lee, Albert Alexander; Ho, Sheng-Yang; Kao, Yu-Lin; Wang, Cuei-Ling; Lian, Yen-Ling; Ueno, Tasuku; Wang, Tsung-Shing Andrew; Yeh, Chih-Kuang; Lin, Yu-Chun (2017): Manipulating Cellular Activities Using an Ultrasound–Chemical

Hybrid Tool. ACS Publications.

https://doi.org/10.1021/acssynbio.7b00162

Retrieved: 09:48, Oct 23, 2017 (GMT)