Manipulating Cellular Activities Using an Ultrasound–Chemical
Hybrid Tool
Version 2 2017-10-12, 13:32
Version 1 2017-10-12, 13:27
Posted on 2017-10-12 - 13:32
We
developed an ultrasound–chemical hybrid tool to precisely
manipulate cellular activities. A focused ultrasound coupled with
gas-filled microbubbles was used to rapidly trigger the influx of
membrane-impermeable chemical dimerizers into living cells to regulate
protein dimerization and location without inducing noticeable toxicity.
With this system, we demonstrated the successful modulation of phospholipid
metabolism triggered by a short pulse of ultrasound exposure. Our
technique offers a powerful and versatile tool for using ultrasound
to spatiotemporally manipulate the cellular physiology in living cells.
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Fan, Ching-Hsiang; Huang, Yao-Shen; Huang, Wei-En; Lee, Albert Alexander; Ho, Sheng-Yang; Kao, Yu-Lin; et al. (2017). Manipulating Cellular Activities Using an Ultrasound–Chemical
Hybrid Tool. ACS Publications. Collection. https://doi.org/10.1021/acssynbio.7b00162
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AUTHORS (12)
CF
Ching-Hsiang Fan
YH
Yao-Shen Huang
WH
Wei-En Huang
AL
Albert Alexander Lee
SH
Sheng-Yang Ho
YK
Yu-Lin Kao
CW
Cuei-Ling Wang
YL
Yen-Ling Lian
TU
Tasuku Ueno
TW
Tsung-Shing Andrew Wang
CY
Chih-Kuang Yeh
YL
Yu-Chun Lin