MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity
Posted on 2017-07-06 - 05:00
Abstract Background Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level. Results Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. Conclusions By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.
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Latrasse, David; JĂŠgu, Teddy; Li, Huchen; de Zelicourt, Axel; Raynaud, CĂŠcile; Legras, StĂŠphanie; et al. (2017). MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.3820504.v1
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AUTHORS (18)
DL
David Latrasse
TJ
Teddy JĂŠgu
HL
Huchen Li
Ad
Axel de Zelicourt
CR
CĂŠcile Raynaud
SL
StĂŠphanie Legras
AG
Andrea Gust
OS
Olga Samajova
AV
Alaguraj Veluchamy
NR
Naganand Rayapuram
JR
Juan Ramirez-Prado
OK
Olga Kulikova
JC
Jean Colcombet
JB
Jean Bigeard
BG
Baptiste Genot
TB
Ton Bisseling
MB
Moussa Benhamed
HH
Heribert Hirt
KEYWORDS
defence gene expressionimpacts chromatin reprogrammingpattern-triggered gene expressionhistone deacetylaseMAP kinase MPK 3microbial-associatedphosphorylates HD 2Bhistone deacetylase HD 2BResults Histone acetylationMAPK-triggered chromatin reprogrammingregulatorimmunity Abstract Background Microbial-associated