Large-Pore Periodic Mesoporous Organosilicas as Advanced
Bactericide Platforms
Version 2 2018-11-16, 17:26
Version 1 2018-11-15, 21:47
Posted on 2018-11-16 - 17:26
Despite
the versatility of periodic mesoporous organosilicas (PMOs),
the bactericide capacity of these hybrid platforms has seldom been
explored. Herein, we describe the synthesis of large-pore phenylene-bridged
PMOs, mesostructured by polyion complex (PIC) micelles (PICPMOs) incorporating
an antibiotic, neomycin B. A key feature of this approach is that
the bioactive molecules are directly encapsulated within the PICPMOs
during their formation. The engineered PICPMOs exhibit a well-ordered
hexagonal mesophase with a molecular-scale crystallinity and large
mesopores (8 nm), which facilitates pH-triggered delivery of the drug.
The results obtained with a pathogenic Escherichia coli strain clearly demonstrate the potential of such PICPMOs for antibacterial
applications.
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Birault, Albane; Molina, Emilie; Toquer, Guillaume; Lacroix-Desmazes, Patrick; Marcotte, Nathalie; Carcel, Carole; et al. (2018). Large-Pore Periodic Mesoporous Organosilicas as Advanced
Bactericide Platforms. ACS Publications. Collection. https://doi.org/10.1021/acsabm.8b00474
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AUTHORS (10)
AB
Albane Birault
EM
Emilie Molina
GT
Guillaume Toquer
PL
Patrick Lacroix-Desmazes
NM
Nathalie Marcotte
CC
Carole Carcel
MK
Mohammad Katouli
JB
John R. Bartlett
CG
Corine Gérardin
MW
Michel Wong Chi Man