Iron-Catalyzed Regiospecific Intermolecular Radical
Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted
Indolines
Posted on 2018-02-22 - 16:19
The first regiospecific catalytic
intermolecular assembly of 2,2-disubstituted
indolines has been developed. This protocol is based on a ligand and
directing group free, iron-catalyzed radical [3 + 2] process, allowing
efficient coupling of different N-sulfonylanilines
with various α-substituted styrenes. Preliminary mechanistic
studies elucidated the radical mechanism involving a reactive and
versatile anilino radical and the importance of iron complex as a
Lewis acid, rendering both the reactivity and regiospecificity of
this transformation.
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Ni, Yang; Yu, Qile; Liu, Qihao; Zuo, Honghua; Yu, Huai-Bin; Wei, Wen-Jie; et al. (2018). Iron-Catalyzed Regiospecific Intermolecular Radical
Cyclization of Anilines: Strategy for Assembly of 2,2-Disubstituted
Indolines. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b00176
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AUTHORS (8)
YN
Yang Ni
QY
Qile Yu
QL
Qihao Liu
HZ
Honghua Zuo
HY
Huai-Bin Yu
WW
Wen-Jie Wei
RL
Rong-Zhen Liao
FZ
Fangrui Zhong