Iron-Catalyzed
Hydrogenation of Amides to Alcohols
and Amines
Version 2 2016-10-03, 14:09
Version 1 2016-08-26, 20:46
Posted on 2016-08-29 - 00:00
This article describes
the iron-catalyzed hydrogenation of unactivated
amides. Under the optimal conditions, a PNP-ligated Fe catalyst affords
25–300 turnovers of products derived from C–N bond cleavage.
This reaction displays a broad substrate scope, including a variety
of 2° and 3° amide substrates. The reaction progress of N,N-dimethylformamide hydrogenation has been monitored in
situ using Raman spectroscopy. This technique enables direct comparison
of the relative activity of the Fe-PNP catalyst to that of its Ru
analogue. Under otherwise identical conditions, the Fe and Ru catalysts
exhibit rates within a factor of 2.
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Rezayee, Nomaan
M.; Samblanet, Danielle C.; Sanford, Melanie S. (2016). Iron-Catalyzed
Hydrogenation of Amides to Alcohols
and Amines. ACS Publications. Collection. https://doi.org/10.1021/acscatal.6b01454
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AUTHORS (3)
NR
Nomaan
M. Rezayee
DS
Danielle C. Samblanet
MS
Melanie S. Sanford