Insight into the Unique Fluorescence Quenching Property
of Metal-Organic Frameworks upon DNA Binding
Version 3 2017-10-16, 14:03
Version 2 2017-10-12, 14:21
Version 1 2017-10-10, 17:18
Posted on 2017-10-16 - 14:03
Metal-organic
frameworks (MOFs) have been successfully used as
efficient quenchers for fluorescent DNA detection. However, the surface
charge property of MOFs can inevitably affect their fluorescence quenching
behavior. Herein, nanoscale MOFs (NMOFs), including MOF nanosheets
and nanoparticles, have been employed to investigate the relationship
between the fluorescence quenching and surface properties of NMOFs.
We find that the positively and negatively charged NMOFs exhibited
totally opposite fluorescence quenching properties toward negatively
charged FAM-labeled double-stranded DNA (dsDNA).
On the contrast, they show negligible influence on the sensing of
positively charged TAMRA-labeled dsDNA. This study
provides a new insight of the fluorescence quenching property of NMOFs
and offers a new concept for construction of ratiometric fluorescence
DNA biosensors.
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Wang, Huai-Song; Liu, Hai-Ling; Wang, Kang; Ding, Ya; Xu, Jing-Juan; Xia, Xing-Hua; et al. (2017). Insight into the Unique Fluorescence Quenching Property
of Metal-Organic Frameworks upon DNA Binding. ACS Publications. Collection. https://doi.org/10.1021/acs.analchem.7b02256
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AUTHORS (7)
HW
Huai-Song Wang
HL
Hai-Ling Liu
KW
Kang Wang
YD
Ya Ding
JX
Jing-Juan Xu
XX
Xing-Hua Xia
HC
Hong-Yuan Chen
KEYWORDS
ds DNAMOF nanosheetsNMOFfluorescence quenchingsurface charge propertyUnique Fluorescence Quenching Propertyratiometric fluorescence DNA biosensorssurface propertiesnanoscale MOFsMetal-Organic FrameworksDNA detectionDNA Binding Metal-organic frameworksTAMRA-labeled ds DNAfluorescence quenching propertyFAM-labeled double-stranded DNAfluorescence quenching propertiesfluorescence quenching behavior