Influence of Charge Density on Host–Guest Interactions
within Amphiphilic Polymer Assemblies in Apolar Media
Version 2 2017-12-07, 20:44
Version 1 2017-12-07, 20:36
Posted on 2017-12-07 - 20:44
The
effects of charge density on supramolecular host–guest
interactions between peptides and reverse micelles are studied using
an amphiphilic random copolymer scaffold. While our classical understanding
of polyvalent electrostatic interactions suggests that the binding
capacity should increase with charge density, our results indicate
that this correlation does not necessarily hold within the nanoscale
environment of reverse micelles. Using four series of different polymers,
we show that peptide binding efficiency depends on the presence of
an optimum charge density inside the reverse micelles. Interestingly,
the distribution of charges does not have a significant effect on
binding. Reverse micelle stability at high charge densities can be
regained by tuning the hydrophilic–lipophilic balance of the
polymer, yet an optimal density dependence remains. Our findings improve
our understanding of host–guest chemistry in confined aqueous
environments.
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Zhao, Bo; Zhuang, Jiaming; Serrano, Mahalia A. C.; Vachet, Richard W.; Thayumanavan, S. (2017). Influence of Charge Density on Host–Guest Interactions
within Amphiphilic Polymer Assemblies in Apolar Media. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.7b02434
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AUTHORS (5)
BZ
Bo Zhao
JZ
Jiaming Zhuang
MS
Mahalia A. C. Serrano
RV
Richard W. Vachet
ST
S. Thayumanavan