Incorporating Fullerenes in Nanoscale Metal–Organic Matrixes: An Ultrasensitive Platform for Impedimetric Aptasensing of Tobramycin

The rational design and preparation of available fullerene@metal–organic matrix hybrid materials are of profound significance in electrochemical biosensing applications due to their unique photoelectric properties. In this work, C₆₀@UiO-66-NH₂ nanocomposites serve as greatly promising materials to modify electrodes and fix aptamers, resulting in a remarkable electrochemical aptasensor for impedimetric sensing of tobramycin (TOB). Nanoscale composites have preferable electroactivity and small particle size with more exposed functional sites, such as Zr­(IV) and −NH₂, to immobilize aptamers for enhanced detection performance. As we know, most of the electrochemical impedance aptasensors require a long time to complete the detection process, but this prepared biosensor shows the rapid quantitative identification of target TOB within 4 min. This work expands the synthesis of functional fullerene@metal–organic matrix hybrid materials in electrochemical biosensing applications.