In vivo laser Doppler holography of the human retina
Posted on 2018-08-06 - 18:43
The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes. To overcome this limitation, we used digital holography to perform laser Doppler perfusion imaging of human retina with near-infrared light. Two imaging channels with a slow and a fast CMOS camera were used simultaneously for real-time narrowband measurements, and offline wideband measurements, respectively. The beat frequency spectrum of optical interferograms recorded with the fast (up to 75 kHz) CMOS camera was analyzed by short-time Fourier transformation. Power Doppler images drawn from the Doppler power spectrum density qualitatively revealed blood flow in retinal vessels over 512 x 512 pixels covering 2.4 x 2.4 mm² on the retina with a temporal resolution down to 1.6 ms. The sensitivity to lateral motion as well as the requirements in terms of sampling frequency are discussed.
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Puyo, Léo; Paques, Michel; Fink, Mathias; Sahel, Jose; Atlan, Michael (2018). In vivo laser Doppler holography of the human retina. Optica Publishing Group. Collection. https://doi.org/10.6084/m9.figshare.c.4136303.v1
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AUTHORS (5)
LP
Léo Puyo
MP
Michel Paques
MF
Mathias Fink
JS
Jose Sahel
MA
Michael Atlan