In vivo imaging-guided microsurgery based on femtosecond laser produced neo-fluorescent compounds in biological tissues

Published on 2018-01-11T20:07:36Z (GMT) by
Femtosecond laser microsurgery has become an advanced method for clinical procedures and biological research. The tissue treated by femtosecond laser can become highly fluorescent, indicating the formation of neo-fluorescent compounds that can naturally label the treated tissue site. We systematically characterized the neo-fluorescence signals produced by femtosecond laser ablation in biological tissues in vivo. Our findings showed that they possess unique fluorescence properties and can be clearly differentiated from endogenous signals and major fluorescent proteins. We further demonstrated that the neo-fluorescent compounds can be used as in vivo labelling agent for biological imaging and guided laser microsurgery.

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Sun, Qiqi; Qin, Zhongya; Wu, Wanjie; Lin, Yue; Chen, Congping; He, Sicong; Li, Xuesong; Wu, Zhenguo; Luo, Yi; Qu, Jianan (2018): In vivo imaging-guided microsurgery based on femtosecond laser produced neo-fluorescent compounds in biological tissues. The Optical Society. Collection.