High-Throughput
and Self-Powered Electroporation System
for Drug Delivery Assisted by Microfoam Electrode
Posted on 2020-10-27 - 10:03
Electroporation
is an effective approach for drug and gene delivery,
but it is still limited by its low-throughput and severe cell damage.
Herein, with a self-powered triboelectric nanogenerator as the power
source, we demonstrated a high-throughput electroporation system based
on the design of biocompatible and flexible polypyrrole microfoam
as the electrode within the flow channel. In particular, to lower
the imposed voltage, one-dimensional (1D) Ag nanowires were modified
on the microfoam electrode to build up a locally enhanced electric
field and reduce cell damage. The self-powered electroporation system
realized a successful delivery of small and large biomolecules into
different cell lines with efficiency up to 86% and cell viability
over 88%. The handle throughput achieved as high as 105 cells min–1 on continuously flowed cells. The
high-throughput and self-powered electroporation system is expected
to have potential applications in the fields of high-throughput drug
and gene delivery for in vitro isolated cells.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Liu, Zhirong; Liang, Xi; Liu, Huanhuan; Wang, Zhuo; Jiang, Tao; Cheng, Yuanyuan; et al. (2020). High-Throughput
and Self-Powered Electroporation System
for Drug Delivery Assisted by Microfoam Electrode. ACS Publications. Collection. https://doi.org/10.1021/acsnano.0c06100
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (11)
ZL
Zhirong Liu
XL
Xi Liang
HL
Huanhuan Liu
ZW
Zhuo Wang
TJ
Tao Jiang
YC
Yuanyuan Cheng
MW
Mengqi Wu
DX
Deli Xiang
ZL
Zhou Li
ZW
Zhong Lin Wang
LL
Linlin Li