Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction
Posted on 2018-04-03 - 05:00
Abstract Background Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge. Results Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients. We report for the first time higher microbial richness and diversity in the systemic microbiome of STEMI patients. More than 12% of post-STEMI blood bacteria were dominated by intestinal microbiota (Lactobacillus, Bacteroides, and Streptococcus). The significantly increased product of gut bacterial translocation (LPS and d-lactate) was correlated with systemic inflammation and predicted adverse cardiovascular events. Following experimental MI, compromised left ventricle (LV) function and intestinal hypoperfusion drove gut permeability elevation through tight junction protein suppression and intestinal mucosal injury. Upon abrogation of gut bacterial translocation by antibiotic treatment, both systemic inflammation and cardiomyocyte injury in MI mice were alleviated. Conclusions Our results provide the first evidence that cardiovascular outcomes post-MI are driven by intestinal microbiota translocation into systemic circulation. New therapeutic strategies targeting to protect the gut barrier and eliminate gut bacteria translocation may reduce or even prevent cardiovascular events post-MI.
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Zhou, Xin; Li, Jing; Guo, Junli; Geng, Bin; Ji, Wenjie; Zhao, Qian; et al. (2018). Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4057958.v1
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AUTHORS (22)
XZ
Xin Zhou
JL
Jing Li
JG
Junli Guo
BG
Bin Geng
WJ
Wenjie Ji
QZ
Qian Zhao
JL
Jinlong Li
XL
Xinlin Liu
JL
Junxiang Liu
ZG
Zhaozeng Guo
WC
Wei Cai
YM
Yongqiang Ma
DR
Dong Ren
JM
Jun Miao
SC
Shaobo Chen
ZZ
Zhuoli Zhang
JC
Junru Chen
JZ
Jiuchang Zhong
WL
Wenbin Liu
MZ
Minghui Zou