Pulse wave is considered a vital physiological signal
in the effective
prevention and diagnosis of cardiovascular diseases, which remain
the leading cause of human mortality. Developing flexible and non-invasive
pressure sensors for detecting subtle pressure changes in blood vessels
has garnered significant attention globally. Here, a flexible and
sphere elastomer structural triboelectric pressure sensor is developed
with the characteristics of great sensitivity, decent durability,
and fast response time for continuous and non-invasive monitoring
of epidermal pulse waves. Leveraging the sphere elastomer structure
on the tribolayer, the contact area significantly enhances the pressure
sensor, resulting in an impressive sensitivity of 1.62 V kPa–1 and a swift response time for real-time pulse monitoring. Furthermore,
the sphere elastomer structure endows the function of a stable supporting
component in the sensor exhibiting excellent mechanical durability
(>20000 cycles). Due to such merits, the pressure sensor is capable
of recognizing pulse signals with detailed information in real-time.
Meanwhile, the flexible pressure sensor enables capture human pulse
waves at different positions and exercise conditions, making it highly
versatile in practical applications. Overall, our proposed pressure
sensor represents a significant advancement in non-invasive pulse
monitoring for the assessment and diagnosis of cardiovascular diseases
and reveals the potential applications in wearable medical electronics.