Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus <i>Aspergillus flavipes</i> 164013

Published on 2020-02-14T15:14:29Z (GMT) by
Three unusual chlorinated PKS-NRPS hybrid metabolites, flavipesides A–C (<b>1</b>–<b>3</b>), were isolated from a strain of marine sponge symbiotic fungus <i>Aspergillus flavipes</i> 164013. Their structures were determined by spectroscopic data analysis, and absolute configurations were assigned by single-crystal X-ray diffraction with ECD spectral analysis. Flavipesides A–C showed potent pancreatic lipase (PL) inhibitory activity with IC<sub>50</sub> values of 0.07–0.23 μM.

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Jiao, Wei-Hua; Xu, Qi-Hang; Ge, Guang-Bo; Shang, Ru-Yi; Zhu, Hong-Rui; Liu, Hong-Yan; et al. (2020): Flavipesides A–C, PKS-NRPS Hybrids as Pancreatic

Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus

flavipes 164013. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.0c00150