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FeCl3 Catalyzed Regioselective C‑Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes

Posted on 2014-02-21 - 00:00
An efficient FeCl3 catalyzed protocol for the synthesis of amino functionalized indolyl­nitro­alkanes from easily available precursor indolyl­nitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolyl­quinoline derivatives.

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